Molecular Systems Biology· Kosonocky CW, Abel AM, Feller AL, Cifuentes Rieffer AE, Woolley PR, Lála J, Barth DR, Gardner T, Bits to Binders Competitors, Ekker SC, Ellington AD, Wierson WA, Marcotte EM.·· 2026-10-08精选AI 评分82
Bits to Binders竞赛验证1.2万条AI设计CAR-T结合域
Validation and analysis of 12,000 AI-driven CAR-T designs in the Bits to Binders competition.
AI 导读
【全文节选总结】Bits to Binders竞赛组织28支队伍用AI方法设计1.2万条80氨基酸的CD20结合minibinder，在CAR-T细胞中经池化增殖筛选出707条具CD20特异性≥2倍富集的设计，命中率在队伍间从0.6%到38.4%不等。
推荐理由
竞赛用CAR-T功能实验检验1.2万条AI设计结合剂，揭示ProteinMPNN偏好带来的表达失败模式。
来源：Molecular Systems Biology · link.springer.com